NEC OncoImmunity AS and Oslo University Hospital Team Up to Develop a Diagnostic for COVID-19 using Artificial Intelligence
OSLO, NORWAY, Oct 08, 2020 - (JCN Newswire) - NEC OncoImmunity AS (NOI), a subsidiary of NEC Corporation (NEC), and Oslo University Hospital (OUH) are pleased to announce that they have recently been awarded a prestigious grant from the Research Council of Norway (RCN) to develop an artificial intelligence (AI) platform that will enable the rapid design of T-cell diagnostics for emerging or endemic infectious diseases. The project will develop a novel T-cell diagnostic for the current COVID-19 pandemic to complement the current serological tests. This will improve the ability to identify immune responses and acquired immunity, which is desperately needed to deal with the COVID-19 crisis.
Current technologies involve extensive trial and error to define exactly which parts of the pathogen induce robust immunity. These so called immunodominant epitopes need to be identified for the general population. These demanding, work-intensive and time-consuming steps are necessary to develop tests to monitor the T-cell response to viruses such as SARS-CoV-2 (the infectious virus that causes COVID-19).
Reliable diagnostic tests to identify immune individuals are critical to overcome the ever-looming threat of COVID-19. The AI based diagnostic to be developed in this project will complement antibody tests and enable individuals who are naturally immune to the virus following infection with SARS-CoV-2 or other seasonal coronaviruses, or who have acquired immunity following vaccination, to be identified.
"Antibody tests are an important aspect of understanding the immune response to the SARS-CoV-2 infection and will remain a mainstay of its diagnosis. However, protective SARS-CoV-2-specific T-cell responses occur in antibody-negative infected individuals who have successfully resolved the infection. In addition, we may already have underlying immunity in the population due to cross-reactivity to endemic seasonal human coronaviruses," said, Professor Ludvig A. Munthe Ph.D., Head of Research and Group Leader, Department of Immunology, Oslo University Hospital.
Although the technology to develop antibody diagnostics is readily available, this is not the case for T-cell diagnostics, which currently represents a "blind spot" for the monitoring of immunity to COVID-19 in the world's population. To address this important gap, NOI and OUH, with the support of RCN, have now committed themselves to develop an AI-designed T-cell diagnostic that monitors the underlying T-cell response to the infection. Developing a reliable T-cell diagnostic comes with specific technological challenges with solutions offered by the NEC Immune Profiler at NOI to cater to the global human population.
"T-cells are known to play a central role for initial and long term immunity against viruses. However, T-cell responses are highly variable between different pathogens and genetic groups in the human population, making the prospect of developing a reliable universal T-cell diagnostics for COVID-19 challenging. This challenge has inspired the scientists at NOI to use our AI to seek out the T-cell response to infection as a diagnostic signal. In this project we look forward to adapting the NEC Immune Profiler and other AI technologies at NEC Corporation and leveraging them to develop a COVID-19 T-cell diagnostic for the diverse genetic makeup in the global human population," said Trevor Clancy Ph.D., Chief Scientific Officer, NEC OncoImmunity AS.
The development of such an AI platform will not only help to contact-trace and control transmission against COVID-19. In fact, the platform developed by NOI and NEC in this project will be to a large degree pathogen/disease agnostic and may be used in future emergency settings to rapidly develop novel diagnostics against new emerging pandemics caused by novel dangerous infectious agents.
"The AI platform will be applied first to the current COVID-19 pandemic. However, we will design this platform to be future-proof and make it applicable to any future emerging infectious agent that could threaten the global population. This will open up new exciting opportunities in the growing infectious disease diagnostics market for our company," said Richard Stratford Ph.D., Chief Executive Officer, NEC OncoImmunity AS.
It has been over a century since the world has encountered a pandemic like COVID-19. The pandemic has taken over one million lives to date, and the spread of COVID-19 around the globe and the associated mortality has been devastating. The pandemic has sparked fears of a chronic worldwide recession. Shut-downs, social distancing, and travel restrictions have reduced the capacity of the global workforce and destroyed many jobs and businesses. The NOI and OUH collaboration mark an important initiative to develop a reliable diagnostic test that can identify immune members of the global population following natural infection with SARS-CoV-2 or other seasonal coronaviruses.
"A reliable T-cell diagnostic to help alleviate the socio-economic and serious health burden caused by COVID-19 will be important for the world community to overcome this present pandemic crisis. We are proud that NEC's AI technology can contribute to the resolution of the COVID-19 threat. As a company that seeks to enhance the well-being of society, NEC will continue to capitalize on research and development that maximizes the strengths of our AI technology to help prevent the spread of COVID-19, and protect the human population against future pandemic threats," said Akira Kitamura, General Manager of the AI Drug Development Division, NEC Corporation.
About NEC OncoImmunity AS
NEC OncoImmunity AS is a bioinformatics company offering proprietary machine learning-based software called the NEC Immune Profiler, which addresses the key knowledge gaps in the prediction of bona fide immunogenic neoantigens for personalized cancer immunotherapy. The NEC Immune Profiler can be used to identify optimal neoantigen targets for truly personalized cancer vaccines & cell therapies in a clinically actionable timeframe, and also facilitate effective patient selection for cancer immunotherapy. For more information, visit NEC OncoImmunity AS at http://www.oncoimmunity.com/.
About NEC Corporation
NEC Corporation has established itself as a leader in the integration of IT and network technologies while promoting the brand statement of "Orchestrating a brighter world." NEC enables businesses and communities to adapt to rapid changes taking place in both society and the market as it provides for the social values of safety, security, fairness and efficiency to promote a more sustainable world where everyone has the chance to reach their full potential. For more information, visit NEC at https://www.nec.com.
For additional information, please also visit NEC Laboratories Europe GmbH at: https://www.neclab.eu
About Oslo University Hospital
Oslo University Hospital is a part of Southern and Eastern Norway Regional Health Authority and an OECI-accredited Comprehensive Cancer Center (CCC). Each year, more than 1.2 million patient treatments are carried out at the hospital, which is the largest of its kind in Scandinavia. Oslo University Hospital is owned by the South-Eastern Norway Regional Health Authority (HSO) and delivers specialist healthcare services to patients all over Norway. Oslo University Hospital is Norway's largest hospital with around 20,000 employees and is responsible for a significant proportion of the medical research and the education of medical personnel in the country. More information about Oslo University Hospital can be found at new windowhttps://oslo-universitetssykehus.no.
Source: NEC Corporation
Sectors: BioTech, Artificial Intel [AI]
Copyright ©2021 JCN Newswire. All rights reserved. A division of Japan Corporate News Network.
More Latest Release >>
BYD to Help Kyoto Reach Japan's 2050 Carbon Neutral Goal
Feb 26, 2021 11:20 JST
DENSO and Yamato Transport Develop D-mobico, Compact Mobile Refrigerator
Feb 25, 2021 19:28 JST
Mazda Production and Sales Results for January 2021
Feb 25, 2021 17:33 JST
Honda Reports Production, Sales and Export Results in January, 2021
Feb 25, 2021 15:27 JST
Toyota's Global Sales and Production Up Year-on-Year in January for Fifth Consecutive Month
Feb 25, 2021 15:12 JST
Chubu Miraiz and MC to Launch New Assisted-Living JV
Feb 24, 2021 14:12 JST
Fujitsu Launches AI-powered Physical Rehabilitation Solution 'HOPE ROMREC' in Japan
Feb 24, 2021 10:39 JST
Toyota Breaks Ground for 'Woven City'
Feb 23, 2021 13:43 JST
Eisai: MHLW Grants Orphan Drug Designation in Japan to Novel FGF Receptor Selective Tyrosine Kinase Inhibitor E7090
Feb 22, 2021 15:40 JST
Eisai Receives Corporate Philanthropy Award for Its Efforts to Realize Human Health Care (hhc) Philosophy
Feb 22, 2021 13:11 JST
Northgate Public Services Becomes NEC Software Solutions UK from July 2021
Feb 22, 2021 12:59 JST
TOYOTA GAZOO Racing heads north in search of further snow success
Feb 19, 2021 18:59 JST
Honda Motor Co., Ltd. Announces New President & CEO
Feb 19, 2021 17:23 JST
MITSUBISHI MOTORS Started Operation of a Rooftop Solar Power System at Its Laemchabang Factory in Thailand
Feb 19, 2021 17:05 JST
Activities Report of Hydrogen Utilization Study Group in Chubu
Feb 19, 2021 14:02 JST
OUTLANDER PHEV Became Europe's Best-selling Plug-in Hybrid SUV in 2020
Feb 18, 2021 16:47 JST
Fujitsu Develops AI Technology to Automatically Differentiate Between Work Tasks in Video Data for Employee Training and Quality Control Purposes
Feb 18, 2021 10:40 JST
SDK Announces 2020 Consolidated Financial Results
Feb 17, 2021 16:00 JST
MITSUBISHI MOTORS: World Premiere of the All-New OUTLANDER
Feb 17, 2021 09:17 JST
MITSUBISHI MOTORS Launches the Refreshed PAJERO SPORT in Indonesia
Feb 17, 2021 09:00 JST