TOP PAGE
ENGLISH
JAPANESE
|
CONNECT WITH US:
Home
About
Services
Contact
Log in
*
Home
Press release
Jul 22, 2021 08:00 JST
Source:
Science and Technology of Advanced Materials
Stimulating blood vessel formation with magnets
Magnetic field could boost blood vessel growth to regenerate damaged tissue.
TSUKUBA, Japan, Jul 22, 2021 - (ACN Newswire) - Magnetic field can be used to stimulate blood vessel growth, according to a study published in the journal Science and Technology of Advanced Materials. The findings, by researchers at the Tecnico Lisboa and NOVA School of Science and Technology in Portugal, could lead to new treatments for cancers and help regenerate tissues that have lost their blood supply.
"Researchers have found it challenging to develop functional, vascularized tissue that can be implanted or used to regenerate damaged blood vessels," says Frederico Ferreira, a bioengineer at Tecnico Lisboa's Institute for Biosciences and Bioengineering. "We developed a promising cell therapy alternative that can non-invasively stimulate blood vessel formation or regeneration through the application of an external low-intensity magnetic field."
Human-donated mesenchymal stromal cells were placed on PVA or gelatin hydrogels containing iron oxide nanoparticles. Applying a magnetic field to the gelatin hydrogel triggered the release of VEGF-A. This was used to treat endothelial cells, stimulating blood vessel formation.
The researchers worked with human mesenchymal stromal cells from bone marrow. These cells can change into different cell types, and also secrete a protein called VEGF-A that stimulates blood vessel formation.
Ana Carina Manjua and Carla Portugal, at the Research Centre LAQV at the NOVA School of Science and Technology, developed two hydrogel supports, made from polyvinyl alcohol (PVA) or gelatin, both containing iron oxide nanoparticles. Cells were cultured on the hydrogels and exposed to a low-intensity magnetic field for 24 hours.
The cells on the PVA hydrogel produced less VEGF-A after the magnetic treatment. But the cells on the gelatin hydrogel produced more. Subsequent lab tests showed that this VEGF-A rich extracts, taken from the cultures on magnet-stimulated gelatin hydrogel, improved the ability of human vascular endothelial cells to sprout into branching blood vessel networks.
Endothelial cells were then placed onto a culture dish with a gap separating them. The conditioned media from magnet-treated mesenchymal stromal cells from the gelatin hydrogel were added to the endothelial cells, moving to close the gap between them in 20 hours. This was significantly faster than the 30 hours they needed when they had not received magnetic treatment. Placing a magnet directly below the dish triggered the mesenchymal stromal cells to close the gap in just four hours.
Finally, VEGF-A extracts produced by magnet-treated mesenchymal stromal cells on gelatin increased blood vessel formation in a chick embryo, although further research is needed to confirm these results.
More work is needed to understand what happens at the molecular level when a magnetic field is applied to the cells. But the researchers say gelatin hydrogels containing iron oxide nanoparticles and mesenchymal stromal cells could one day be applied to damaged blood vessels and then exposed to a short magnetic treatment to heal them.
The team suggests that magnet-treated cells on PVA, which produce less of the growth factor, could be used to slow down blood vessel growth to limit the expansion of cancer cells.
Further information
Frederico Castelo Ferreira
Universidade de Lisboa
Email:
frederico.ferreira@ist.utl.pt
Carla Portugal
Universidade Nova de Lisboa
Email:
cmp@fct.unl.pt
Ana Carina Baeta Manjua
Universidade de Lisboa
Email:
carina.manjua@tecnico.ulisboa.pt
About Science and Technology of Advanced Materials Journal
Open access journal STAM publishes outstanding research articles across all aspects of materials science, including functional and structural materials, theoretical analyses, and properties of materials. Website:
https://www.tandfonline.com/toc/tsta20/current
Dr. Yoshikazu Shinohara
STAM Publishing Director
Email:
SHINOHARA.Yoshikazu@nims.go.jp
Press release distributed by ResearchSEA for Science and Technology of Advanced Materials.
Source: Science and Technology of Advanced Materials
Sectors: Science & Nanotech, BioTech
Copyright ©2024 ACN Newswire. All rights reserved. A division of Asia Corporate News Network.
Related Press Release
A new spin on materials analysis
April 17 2024 22:00 JST
Kirigami hydrogels rise from cellulose film
April 12 2024 18:00 JST
Sensing structure without touching
February 27 2024 08:00 JST
Nano-sized probes reveal how cellular structure responds to pressure
November 21 2023 07:00 JST
Machine learning techniques improve X-ray materials analysis
November 17 2023 10:00 JST
A bio-inspired twist on robotic handling
November 14 2023 20:00 JST
GPT-4 artificial intelligence shows some competence in chemistry
October 17 2023 08:00 JST
Closing the loop between artificial intelligence and robotic experiments
August 24 2023 09:00 JST
Machine intelligence for designing molecules and reaction pathways
May 24 2023 09:00 JST
Face-down: Gravity's effects on cell movement
May 13 2023 00:00 JST
More Press release >>
Latest Press Release
Fujitsu SX Survey reveals key success factors for sustainability
Apr 23, 2024 10:25 JST
Fujitsu and METRON collaborate to drive ESG success: slashing energy costs, boosting productivity with new manufacturing industry solutions
Apr 22, 2024 16:09 JST
NEC Strengthens Commitment to Space Industry with Investment in Seraphim Space Venture Fund II
Apr 22, 2024 15:09 JST
Soft Space Launches the First and Only JCB Payment Gateway in Malaysia
Apr 22, 2024 15:00 JST
TOYOTA GAZOO Racing takes a one-two in Croatian thriller
Apr 22, 2024 10:47 JST
First-ever Mazda CX-80 Crossover SUV Unveiled in Europe
Apr 19, 2024 13:50 JST
Fujitsu develops technology to convert corporate digital identity credentials, enabling participation of non-European companies in European data spaces
Apr 19, 2024 10:17 JST
Mitsubishi Heavy Industries and NGK to Jointly Develop Hydrogen Purification System from Ammonia Cracking Gas
Apr 18, 2024 17:01 JST
Toyota Launches All-New Land Cruiser "250" Series in Japan
Apr 18, 2024 13:39 JST
Fujitsu and Oracle collaborate to deliver sovereign cloud and AI capabilities in Japan
Apr 18, 2024 11:14 JST
Eisai: Research on Treatments for Alzheimer's Disease Based on Its Pathological Mechanisms Recieves Award for Science and Technology (Research Category)
Apr 18, 2024 10:53 JST
All-New Triton Confirmed as First Double-Cab Pickup Truck to Achieve 2024 Five-Star ANCAP Safety Rating
Apr 18, 2024 09:22 JST
Eisai's Antiepileptic Drug Fycompa Injection Formulation Launched In Japan
Apr 17, 2024 16:17 JST
Honda Unveils Next-generation EV Series for China
Apr 17, 2024 12:15 JST
Lexus presents Time at the 2024 Milan Design Week
Apr 16, 2024 18:49 JST
Mitsubishi Corporation Announces Participation in a DAC Project in Louisiana, USA
Apr 16, 2024 14:36 JST
New circuit challenge for TOYOTA GAZOO Racing
Apr 15, 2024 17:21 JST
TOYOTA GAZOO Racing back on asphalt for Croatian challenge
Apr 12, 2024 19:36 JST
Heidelberg Materials North America Announces Latest Milestone in Edmonton CCUS Project
Apr 12, 2024 14:39 JST
MHIAEL Completes Expansion of the its Nagasaki Plant for Manufacture of Aero Engine Combustors
Apr 11, 2024 18:08 JST
More Latest Release >>