CONNECT WITH US:
Jun 27, 2022 18:00 JST
Science and Technology of Advanced Materials
Novel patching material for bone defects
Scientists at Tokyo Medical and Dental University have discovered a new type of bone repairing material that could be used to more precisely fix bone defects.
TSUKUBA, Japan, Jun 27, 2022 - (ACN Newswire) - Ceramics and metals have been used for a while as structural materials to repair bones and joints. In the past, scientists engineered bioinert materials, which do not bond to bones directly; bioactive materials that can bond to bones; and bio-absorbable materials that are categorized in bioactive materials but they are absorbed by the body over time and are replaced by advancing bone tissue.
A new bio-responsive ceramic can be used to repair bone defects
With an enzyme found in blood, different types of salts were converted to hydroxyapatite, a bone mineral
Now, a fourth type of bone repairing materials has been found: a bio-responsive ceramic that interacts with an enzyme found in blood to be absorbed into the body at a precise and predictable rate.
The research was done by Taishi Yokoi, an associate professor at the Institute of Biomaterials and Bioengineering at Tokyo Medical and Dental University, and his colleagues. The study was published in May in Science and Technology of Advanced Materials.
"Extending healthy life expectancy is an important issue for all of us," Yokoi says. "Bone repairing materials aid in the recovery of bone defects and help improve quality of life."
At the heart of this discovery is a biological reaction: an enzyme called alkaline phosphatase (ALP), which is present in human serum and reacts with various phosphate esters to generate bone mineral known as hydroxyapatite.
The scientists mimicked this process using a simulated body fluid that contained the enzyme ALP. They placed four different salts in a simulated body fluid containing or lacking the enzyme ALP. The salts were calcium salts of methyl phosphate (CaMeP), ethyl phosphate (CaEtP), butyl phosphate (CaBuP) and dodecyl phosphate (CaDoP). The phosphate component of each of these salts has an alkyl group at its end - a chain composed of hydrogen and carbon atoms - of differing lengths.
The scientists found that the first three salts were converted to hydroxyapatite, but only in the presence of ALP. Interestingly, the length of the alkyl group on the phosphate ester determined the rate at which this reaction happens. With more research, the scientists think that this could allow greater control of the bone healing process in the body.
"We expect the findings of this study will be applied towards designing and developing novel bone-repairing materials with precisely controlled degradation and resorption rates inside the body," says Yokoi.
Tokyo Medical and Dental University
About Science and Technology of Advanced Materials (STAM)
Open access journal STAM publishes outstanding research articles across all aspects of materials science, including functional and structural materials, theoretical analyses, and properties of materials.
STAM Publishing Director
Press release distributed by Asia Research News for Science and Technology of Advanced Materials.
Source: Science and Technology of Advanced Materials
Sectors: Science & Nanotech, BioTech, Healthcare & Pharm
Copyright ©2023 ACN Newswire. All rights reserved. A division of Asia Corporate News Network.
Related Press Release
Nano-sized probes reveal how cellular structure responds to pressure
November 21 2023 07:00 JST
Machine learning techniques improve X-ray materials analysis
November 17 2023 10:00 JST
A bio-inspired twist on robotic handling
November 14 2023 20:00 JST
GPT-4 artificial intelligence shows some competence in chemistry
October 17 2023 08:00 JST
Closing the loop between artificial intelligence and robotic experiments
August 24 2023 09:00 JST
Machine intelligence for designing molecules and reaction pathways
May 24 2023 09:00 JST
Face-down: Gravity's effects on cell movement
May 13 2023 00:00 JST
Polymer protection for vaccines and drugs
December 09 2022 23:00 JST
Revealing crystal structures robotically
December 02 2022 20:00 JST
New data extracted from old for materials databases
November 07 2022 23:00 JST
More Press release >>
Latest Press Release
GC Collaborates with MHI to explore the utilization of hydrogen, ammonia and CCS technology to develop a large-scale petrochemical plant to achieve Net Zero
Dec 01, 2023 17:22 JST
NEC named among IAM's 2023 Asia IP Elite
Dec 01, 2023 14:50 JST
Eisai's Sales Subsidiary Collaborates with Ministry of Public Health (MOPH) in Thailand
Nov 30, 2023 16:25 JST
Boosting Growth Investment to Power Mobility Company Transformation Toyota-DENSO Capital Ties Revised
Nov 30, 2023 16:17 JST
Olympus's Net-Zero Targets Approved by SBTi
Nov 30, 2023 11:00 JST
Fujitsu and Macquarie University establish new research lab to accelerate development of human sensing and generative AI technologies
Nov 30, 2023 09:34 JST
NEC X and Entrepreneurs Roundtable Accelerator (ERA) Forge Strategic Partnership to Advance East Coast-based Startups
Nov 29, 2023 18:37 JST
MHI Selected as Core Company for New Research Reactor for JAEA
Nov 29, 2023 18:22 JST
Toyota: Sales, Production, and Export Results for October 2023
Nov 29, 2023 16:17 JST
Toyota Re-introduces the Land Cruiser "70" in Japan
Nov 29, 2023 13:30 JST
Mitsubishi Shipbuilding Holds Christening and Handover Ceremony in Shimonoseki for Demonstration Test Ship for Liquefied CO2 Transport
Nov 28, 2023 17:47 JST
Hitachi awarded Sustainable Markets Initiative 2023 Terra Carta Seal
Nov 28, 2023 17:43 JST
MHI Succeeded Combustion Test of Ammonia Single-Fuel Burners
Nov 28, 2023 16:40 JST
JCB partners with FrenchSys to boost card acceptance across France
Nov 28, 2023 12:00 JST
Toyota Launches IMV 0 in Thailand Providing Mobility to Make People's Lives Better through Customizability
Nov 27, 2023 17:30 JST
MHI and Orica Announce Collaboration to Explore Emissions Reduction Opportunities
Nov 27, 2023 15:29 JST
Mitsubishi Motors to Launch the New Minicab EV Electric Commercial Vehicle in Japan in December
Nov 24, 2023 16:32 JST
DOCOMO to Showcase Diverse Technologies at docomo Open House '24
Nov 22, 2023 20:39 JST
Renewal of O&M Services Contract for APM System at Dubai International Terminal 3
Nov 22, 2023 20:21 JST
Hitachi Energy unveils new emission-free alternative to diesel- powered generators
Nov 22, 2023 20:05 JST
More Latest Release >>